Research Paper Volume 14, Issue 10 pp 4305—4325
MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models
Figure 1. MRTF-A alleviated cognitive impairment in Tg2576 mice. (A) MRTF-A expression in the hippocampus of WT and Tg2576 mice was analyzed after transfected with or without LV-MRTF-A. Data represent means ± SEM from 5 mice per group. (B) The diagram of the treatment of LV-MRTF-A and the assessment of cognitive function in Tg2576 mice. (C–F) The water maze test (C, D), the probe test (E) and the step-through type passive avoidance test (F) were carried out in WT or Tg2576 mice. Data represent means ± SEM from 14-12 mice per group, *P < 0.05, **P < 0.01 and ***P < 0.001 (two-way ANOVA, Tukey’s Multiple Comparison Test).