Research Paper Volume 14, Issue 10 pp 4305—4325
MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models
Figure 2. MRTF-A reduced Aβ-induced neurotoxicity in Tg2576 mouse hippocampus. (A) Representative image of staining with anti-Aβ (green) and DAPI (blue) in the CA1 areas of Tg2576 mice treated with LV-MRTF-A or not. (B, C) Western blot and quantitative analysis for APP and BACE1 genes. Data are presented as mean ± SEM from 5 mice per group, *P < 0.05 (one-way ANOVA, Tukey’s Multiple Comparison Test). (D, E) Nissl staining for the neuron morphological changes. The number of survival neurons of CA3 areas was analysis. Data represent means ± SEM from 5 mice per group, *P < 0.05, **P < 0.01 and ***P < 0.001 (one-way ANOVA, Tukey’s Multiple Comparison Test).