Research Paper Volume 14, Issue 10 pp 4305—4325
MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models
Figure 3. MRTF-A rescued autophagy deficit in Tg2576 mice. (A–D) Immunofluorescence staining and quantitative analysis for LC3B (A, B); simultaneously western blot and quantitative analysis for Beclin1 and SQSTM1/p62 protein expressions (C, D). Data represent means ± SEM from 3 mice per group, *P < 0.05, **P < 0.01 and ***P < 0.001 (one-way ANOVA, Tukey’s Multiple Comparison Test). (E) Representative transmission electron microscopic images in the hippocampus. Red arrows depict autophagolysosoms and blue arrows depict autolysosomes.