Research Paper Volume 14, Issue 10 pp 4305—4325
MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models
Figure 5. Detection and verification of miRNA microarray in Aβ-treated SH-SY5Y cells. (A) MRTF-A increased cell viability that had been reduced by Aβ1-42 exposure (n=6). (B) Microarray cluster analysis(n=3). AM: Aβ+LV-MRTF-A, M: normal+LV-MRTF-A, C: normal+LV-NEG, A: Aβ+LV-NEG. (C) Venn plots showed DEMs. (D) The miR-1273g-3p level was analyzed by RT-PCR. Data represent means ± SEM of 3 independent experiments. *P < 0.05, **P < 0.01 and ***P < 0.001 (one-way ANOVA, Tukey’s Multiple Comparison Test).