Research Paper Volume 14, Issue 6 pp 2607—2627

2, 3, 5, 4’-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injury-induced pathophysiology


Figure 6. Administration of THSG increases the number of hippocampal immature neurons in the subgranular zone of dentate gyrus post TBI. (A) Illustrations of the region of interest with red square in the brain section sample. (B) Representative immunofluorescence staining by anti-doublecortin (DCX, a marker for immature neurons, green) and counterstained with DAPI (blue), 21 days after THSG treatments in the subgranular zone of dentate gyrus. Labeling co-localization is shown with white arrows in the merged images. Scale bar = 100 μm. Mice were divided into three groups: Sham + Vehicle, Sham + THSG, TBI + vehicle, and TBI + THSG groups. (C) Quantitative results of the expression of DCX shown as the fold of the Sham + Vehicle group. Data represented as the mean ± SEM (n=6 for each group). NS = no significantly difference; *, P < 0.05; **, P < 0.01 between groups.