Priority Research Paper Volume 14, Issue 6 pp 2442—2461

Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice


Figure 1. mTORC1 and mTORC2 composition. mTORC1 has core components mTOR, mLST8 and RAPTOR, and is associated with inhibitory regulators DEPTOR and PRAS40. mTORC2 has core components mTOR, mLST8, RICTOR and mSIN1, and is associated with inhibitory regulator DEPTOR and positive regulator PROTOR1.