Priority Research Paper Volume 14, Issue 6 pp 2442—2461
Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice
Figure 8. Model of TSC and mTORC1 signaling in GHRKO/Snell dwarf mice. In comparison with wildtype mice, GHRKO and Snell dwarf mice have higher TSC activity, shown by increased TSC1 and TSC2 protein levels, and lower TSC2 phosphorylation. Elevated TSC signaling might inhibit the mTORC1 activity of phosphorylating downstream targets. GHRKO and Snell dwarf liver have lower DEPTOR and PRAS40 levels but these changes are not responsible for the lower mTORC1 activity observed in these mice.