Research Paper Volume 14, Issue 6 pp 2475—2506

Figure 3. Targets associated with hallmarks of aging. Age-associated targets and common targets (n = 145) were mapped to the corresponding hallmark(s) of aging based on the literature. For novel targets, their participating pathways were also used for the assessment of their association with the hallmark(s) of aging. The four targets connected to all hallmarks (AKT1, MTOR, SIRT1 and IGF1) are shown in the inner circle of the plot. The target names are labeled in blue for age-associated targets, and black for common targets. Targets annotated as cancer driver genes in the NCG7.0 database are underlined.