Adipose-derived mesenchymal stem cells may reduce intestinal epithelial damage in ulcerative colitis by communicating with macrophages and blocking inflammatory pathways: an analysis <i>in silico</i>

Nan Zhang; Yixuan Chen; Chengyu Huang; Mengxin Wei; Ting Li; Yufeng Lv; Qiong Song; Shaowen Mo

doi:doi:10.18632/aging.203964

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Research Paper Volume 14, Issue 6 pp 2665—2677

Adipose-derived mesenchymal stem cells may reduce intestinal epithelial damage in ulcerative colitis by communicating with macrophages and blocking inflammatory pathways: an analysis in silico

Figure 1. Single-cell transcriptomic profiles from colon biopsies from UC patients and healthy individuals. (A) Study design. (B) 2d visualization of 51 clusters of cells in healthy controls (up) and UC patients (down) on the UMAP plot. (C) Violin plots of specific marker genes in all types in healthy individuals. (D) Ridge plot. Expression of marker genes common to healthy individuals (left) and UC patients (right). (E) The heat map showing expression of UC-specific marker genes in healthy individuals (left) and UC patients (right). UMAP: uniform manifold approximation and projection for dimension reduction. UC: ulcerative colitis.