Research Paper Volume 14, Issue 7 pp 3070—3083
Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer’s disease mice model
Figure 3. Exosomes from hypoxia-pretreated adipose-derived mesenchymal stem cells had a greater therapeutic effect at improving cognitive function when delivering circ-Epc1. (A) Heat map showing the differentially expressed circRNAs. (B) Volcano plot showing the upregulated and downregulated circRNAs from exosomes derived from ADSCs (Ex)o and hypoxia-pretreated ADSC exosomes (HExo). (C) RT-qPCR detection showing the expression of 10 upregulated circRNAs between Exo and HExo. Data are the means ± SD. *P < 0.05, ***P < 0.001 vs. Exo. (D) The chromosomal location of circ-Epc1.