Research Paper Volume 14, Issue 7 pp 3084—3104
Mechanisms of action of triptolide against colorectal cancer: insights from proteomic and phosphoproteomic analyses
Figure 1. Global proteomic and phosphoproteomic analysis of colorectal cancer cells. (A) Schematic of the experimental workflow; LC, liquid chromatography; MS, mass spectrometry; TMT, tandem mass tags. (B) Numbers of proteins whose levels were significantly higher (red) or lower (blue) in triptolide-treated cell cultures than in control cultures. (C) Numbers of differentially expressed proteins in different subcellular compartments. (D) Numbers of sites in proteins whose phosphorylation was significantly higher (red) or lower (blue) in triptolide-treated cell cultures than in control cultures. (E) Numbers of differentially phosphorylated proteins in different subcellular compartments.