Research Paper Volume 14, Issue 7 pp 3105—3128
Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway
Figure 5. The influence of circ_6014 on its target gene NTRK2 and the downstream PIK3CA/AKT signaling pathway. (A, B) Relative expression of NTRK2 in the MDA-MB-231 and MCF-7 cells transfected with siRNAs or circ_6014 plasmids. (C) Protein levels of NTRK2, PIK3CA, p-AKT, and AKT in MDA-MB-231 cells after decreasing or increasing the expression of circ_6014. (D, E) Quantitative statistics of protein expression levels in MDA-MB-231 cells. (F) Protein levels of NTRK2, PIK3CA, p-AKT, and AKT in MCF-7 cells after decreasing or increasing the expression of circ_6014. (G, H) Quantitative statistics of protein expression levels in MCF-7 cells. *p < 0.05, **p < 0.01, ***p < 0.001.