Research Paper Volume 14, Issue 7 pp 3129—3142

Figure 3. PPI network analysis and miRNA target gene prediction. (A) PPI network of the DEGs. (B) The hub genes identified from the PPI network. (C) The binding sites of mRNAs and miRNAs were plotted. (D) Venn diagram for intersection of DEGs from GSE24548 and GSE76604 showed the miRNAs such as miR-29b. (E) miRNA and mRNA interaction network. (F) Through GSEA, we found that miR-29 was enriched. (G) The expression of miR-29 was lower in MI group. (H, I) Correlation analyses between mTOR and HIF-1α and between HIF-1α and VEGF indicated that HIF-1α was positively correlated with mTOR and VEGF, respectively.