Research Paper Volume 14, Issue 7 pp 3129—3142

Figure 6. Effect of miR-29 inhibition on the expressions of proteins involved in the PI3K\mTOR\HIF1α\VEGF pathway in vivo. (A) Results showed that the protein expressions of p-PI3K, p-mTOR, HIF-1α, and VEGF were elevated in miR-29 inhibition group compared with those in model group. (B) The relative miR-29 fold change was tested by qPCR, and it was found that the miR-29 level was decreased in model group compared with that in control group, and miR-29 inhibition lentivirus group exhibited the lowest miR-29 level among 3 groups. Data were presented as mean ± SE (**P<0.01). PI3K: phosphoinositide 3 kinase; mTOR: mammalian target of rapamycin; HIF-1α: hypoxia-inducible factor-1α; VEGF: vascular endothelial growth factor.