Research Paper Volume 14, Issue 7 pp 3129—3142

Figure 7. Effect of miR-29 inhibition on the expressions of proteins involved in the PI3K\mTOR\HIF-1α\VEGF pathway in endothelial cells. (A) Results showed that the protein expressions of PI3K, mTOR, HIF-1α, and VEGF in endothelial cells rose in miR-29 inhibition group compared with those in control group. Besides, (B) the endothelial tube formation assay results displayed that miR-29 inhibition increased the number of tubes, and PI-103 (the specific inhibitor for PI3K signals) almost inhibited the tube formation. Data were presented as mean ± SE (**P < 0.01). PI3K: phosphoinositide 3 kinase; mTOR: mammalian target of rapamycin; HIF-1α: hypoxia-inducible factor-1α; VEGF: vascular endothelial growth factor; NC: negative control.