Research Paper Volume 14, Issue 7 pp 3276—3292
An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis
Figure 4. Construction of the prognostic model. (A) Through univariate COX analysis, we finally obtained 11 genes related to immune subtypes with prognostic values. There were 7 genes with HR>1, which were marked in red, and 4 genes with HR<1, which were marked in green. (B, C) Then, we performed LASSO regression analysis on these 11 genes, and the minimum lambda value was 0.023. We finally obtained 7 modeling genes, which were ADH4, ANP32B, FTCD, PON1, SPP1, SQSTM1, and YBX1. Risk score = ADH4*(-0.050) + ANP32B*0.136 + FTCD*(-0.038) + PON1(-0.040) + SPP1*0.015 + SQSTM1*0.182 +YBX1*0.376. We then divided the sample into high-risk groups and low-risk values based on the median risk score.