Research Paper Volume 14, Issue 8 pp 3400—3415

Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis

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Figure 1. Differential expression of circRNAs in normal and OA specimens. (A) Hierarchical clustering analysis of the differentially expressed circRNAs between 4 individuals normal and 4 individuals OA specimens; (B) Scatter plot of circRNAs expression between normal and OA specimens. The circRNAs below the bottom green line and above the top green line illustrate >2.0-fold changes between the normal and OA specimens. (C) Volcano plots of the differentially expressed circRNAs. The red point in the plot represents the differentially down or up-regulated circRNAs with statistical significance. (DG) Expression of significant circRNAs in normal and OA specimens.