Research Paper Volume 14, Issue 8 pp 3400—3415

Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis

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Figure 6. Silencing of Circ_0000423 suppresses bone resorption induced by ACLT in vivo. (A) Three-dimensional micro-CT images of frontal views of the knee joints at 8 weeks after the operation. (B) Sagittal views of medial compartment subchondral bone. (C) Quantitative analysis of BV, BV/TV, Tb.Sp, Tb.N and Tb.Th. P-values were computed vs. controls group* or ACLT group#; (*, #) P < 0.05. (Scale bar = 1 mm).