MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma <i>in vivo</i> and <i>in vitro</i> via the MEK1-mediated ERK-MMP signaling pathway

Mingbo Wang; Chao Huang; Wenda Gao; Yonggang Zhu; Fan Zhang; Zhenhua Li; Ziqiang Tian

doi:doi:10.18632/aging.204028

← Back

Research Paper Volume 14, Issue 8 pp 3540—3553

MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma in vivo and in vitro via the MEK1-mediated ERK-MMP signaling pathway

Figure 4. The MAP2K1 (MEK1) gene and ERK-MMP pathway were implicated in ESCC progression. Gene expression profiles in combination with gene ontology (GO) and KEGG pathway analysis was performed; (A) The results of the Go pathways from the data in GSE161533 dataset; (B) the results of the Go pathways from the data in GSE17351; (C) partial results of the KEGG pathways from the data in GSE17351; (D and E) the activation of matrix metalloproteinases signaling pathway and ERK signaling pathway were enriched in ESCC and appeared to be strongly correlated to with MEK1.