Research Paper Volume 14, Issue 8 pp 3554—3568

Figure 1. Decreased claudin-5 level in AD and elder mice. (A, B) The APP/PS1 mice exhibited increased Aβ protein level in hippocampal region (n = 4 per group; two-tailed Student’s t-test). (C, D) Decreased claudin-5 protein level in hippocampus of the APP/PS1 mice (n = 4 per group; two-tailed Student’s t-test). (E) Decreased claudin-5 mRNA level in hippocampus of APP/PS1 mice (n = 6 per group; two-tailed Student’s t-test). (F, G) The elder mice exhibited increased Aβ protein level in hippocampal region (n = 4 per group; two-tailed Student’s t-test, P = 0.001). (H, I) Decreased claudin-5 protein level in hippocampus of elder mice (n = 4 per group; two-tailed Student’s t-test). (J) Decreased claudin-5 mRNA level in hippocampus of elder mice (n = 6 per group; two-tailed Student’s t-test). Data show mean ± s.e.m. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.