Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks

Zixuan Wu; Zhixiang Cai; Hongshuo Shi; Xuyan Huang; Minjie Cai; Kai Yuan; Peidong Huang; Guoqi Shi; Tao Yan; Zhichao Li

doi:doi:10.18632/aging.204030

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Research Paper Volume 14, Issue 8 pp 3569—3596

Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks

Figure 5. Predicting TF and target genes of miRNAs. (A) Top 10 TF of DE-miRNAs (SP1, SP4, KLF7EGR1, HNF4A, POU2F1, GABPA, ETS1, CTCF, and RREB1). (B) Top 10 TF of up-regulated DE-miRNAs (SP1, SP4, KLF7, EGR1, HNF4A, CTCF, POU2F1, NFYA, GABPA, and RREB1). (C) Top 10 TF of down-regulated DE-miRNAs (SP1, SP4, KLF7, EGR1, HNF4A, POU2F1, GABPA, ETS1, MEF2A, and NFIC).