Research Paper Volume 14, Issue 9 pp 3887—3909

Ox-LDL-mediated ILF3 overexpression in gastric cancer progression by activating the PI3K/AKT/mTOR signaling pathway


Figure 7. ILF3 was involved in the regulation of PI3K/AKT/mTOR signaling pathway. The effect of ILF3 on PI3K/AKT/mTOR signaling pathway was verified with western blot. ILF3-specific small interference RNA (si-ILF3) and statins treatment significantly inhibited PI3K/AKT/mTOR signaling pathway. The expression of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR were significantly downregulated compared to control group. And the expression of PI3K, AKT and mTOR and p-mTOR did not change significantly.