Research Paper Volume 14, Issue 10 pp 4376—4389

Figure 1. has_circ_0069313 was upregulated in OSCC and predicts poor prognosis. (A) The graphic illustration of has_circ_0069313, the specific primer was designed to target the junction. (B) The relative level of has_circ_0069313 in our in-house database. 50 paired OSCC and normal tissues were collected and subjected to qRT-PCR, the RNA level was detected using junction-specific primers. (Student’s two-tailed paired test, ^***p < 0.001). (C) The relative level of has_circ_0069313 in patients with different TNM stages in our in-house database. The 50 OSCCs were divided into 4 TNM stages and the RNA level was detected and normalized. (Student’s two-tailed paired test, ^***p < 0.001). (D) The overall survival analysis of the 50 OSCC patients. Patients were divided into two groups with the mean level of has_circ_0069313 as the cutoff. The overall survival analysis was applied. (E) The relative has_circ_0069313 level in OSCC cell lines and normal epithelial cells.