Priority Research Paper Volume 14, Issue 10 pp 4195—4210
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Figure 4. LC3B immunoreactivity in the liver and heart was increased by chloroquine treatment. In the heart tissue, a strong immunostaining was visible in the smooth muscle layer of both arterioles and venules from the parenchyma of treated animals as compared to controls (A vs B). In the liver, LC3B immunostaining showed a diffuse granular pattern in the cytoplasm of hepatocytes that was more intense in treated animals as compared to controls (C vs D). Enlarged images are shown for controls (E) and treatment (F). N = 10 for each group.