Priority Research Paper Volume 14, Issue 10 pp 4195—4210
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Figure 6. Higher doses of CQ attenuated proteasome activity in the liver and heart. Treatment with increasing doses of chloroquine significantly reduced proteasome activity in the liver at a dose of 100 mg/kg (A), whereas proteasomal activity in the heart was reduced only at 200 mg/kg (B). Data are given as arbitrary fluorescence units per mg protein as indicated in the materials and method section of the manuscript. N = 5 for each group.