CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database

Jinyan Wang; Dongmei Qin; Lingling Ye; Li Wan; Fen Wang; Yan Yang; Yajun Ma; Hui Yang; Zhaohui Yang; Meili Chen; Wen Jiang; Quan&#x2019;an Zhang

doi:doi:10.18632/aging.204081

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Research Paper Volume 14, Issue 9 pp 4158—4175

CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database

Figure 3. Heatmaps, venn plots, GO and KEGG enrichment analyses. (A, B) Heatmaps of DEGs obtained by comparison between high Stromal/Immune Score samples with low Stromal/Immune Score samples. p<0.05 and log2^FC >1 were set up to search the DEGs; (C) Venn plots displayed the commonly up-regulated or down-regulated DEGs shared by Immune Score and Stromal Score; (D) GO enrichment analysis of 223 DEGs, p<0.05 was considered to be statistically significant; (E–G) KEGG enrichment analysis of 223 DEGs, p<0.05 was considered to be statistically significant; BP: biological process; CC: cell component; MF: molecular function.