Research Paper Volume 14, Issue 10 pp 4513—4529
The bioinformatics and experimental analysis of the novel roles of virus infection-associated gene CDC20 for prognosis and immune infiltration in hepatocellular carcinoma
Figure 3. Associations between CDC20 and clinicopathological parameters in HCC. (A) Compared to normal liver tissues, the mRNA expression of CDC20 was increased in hepatocellular carcinoma tissues from four public HCC datasets. (B) TNM plot also showed the increased mRNA expression of CDC20 in hepatocellular carcinoma tissues. (C) Compared with the random normal liver tissues, the protein expression of CDC20 was increased in HCC tissues (the Human Protein Atlas, THPA). (D and E) qPCR and western blot showed that compared with the normal hepatocyte cell line L02, CDC20 expression was increased in hepatocellular carcinoma cell lines HepG2 and SK-Hep1. (F and G) The correlation of CDC20 with the tumor grades and cancer stages in patients with HCC.