A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer

Xiaotian Xu; Huideng Wang; Xinhui Li; Xiaoqun Duan; Yuhui Wang

doi:doi:10.18632/aging.204116

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Research Paper Volume 14, Issue 11 pp 4858—4873

A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer

Figure 9. TGFBR2 is necessary for ALG10-induced stemness of CRC cells in vivo. (A) Tumor images derived from different types of HT-29 cells as indicated. (B) Tumor formation ratio of the HT-29 cells as described in (A) was calculated. (C) The 1/(stem cell frequency) was determined for the HT-29 as described in (A) using an ELDA: Extreme Limiting Dilution Analysis (http://bioinf.wehi.edu.au/software/elda/). (D) The difference in stem cell frequencies between any groups described in (C) was measured using an ELDA: Extreme Limiting Dilution Analysis (http://bioinf.wehi.edu.au/software/elda/). (E) The difference in stem cell frequencies between two groups as indicated was measured using an ELDA: Extreme Limiting Dilution Analysis (http://bioinf.wehi.edu.au/software/elda/).