Research Paper Volume 14, Issue 16 pp 6507—6519
miR-141 exacerbates lung ischemia-reperfusion injury by targeting EGFR/β-catenin axis-mediated autophagy
Figure 1. Expression of miR-141 upregulates in lung tissues and PMVECs of I/R injury. (A) Blood gas analyzer was used to detect the blood gas in arterial blood in left ventricle of mice. (B) The statistical graph of W/D ratio of lung tissues of mice. (C) HE staining results of lung tissues (× 400) and lung injury scores. TUNEL staining (D) and flow cytometry assay (E) was used to detect the apoptosis of mouse lung cells (× 200) and PMVECs. The expression of miR-141 in mouse lung tissues (F) and PMVECs (G) were determined by RT-qPCR. * p < 0.05 was considered statistically significant. The experiment was repeated three times independently. Results were expressed as the mean ± SD.