Research Paper Volume 14, Issue 16 pp 6594—6604
MiR-375 mitigates retinal angiogenesis by depressing the JAK2/STAT3 pathway
Figure 2. Inhibition of miR-375 promotes cell proliferation and angiogenesis in RMECs. (A) Cell viability was increased by the inhibition of miR-375 in RMECs. (B, C) The incorporation of BrdU (B) and the protein levels of PCNA (C) were facilitated by the treatment with anti-miR-375. (D, E) The inhibition of miR-375 enhanced cell migration (D) and tube formation (E) in RMECs. Scale bar: 100 μm (D) and 500 μm (E), respectively. All values are represented as the mean ± standard error of the mean. n = 3 per group. *P < 0.05.