Research Paper Volume 14, Issue 18 pp 7378—7389
Fasudil inhibits hepatic artery spasm by repressing the YAP/ERK/ ETA/ETB signaling pathway via inhibiting ROCK activation
Figure 2. Fasudil inhibited the RhoA/ROCK/ERK1/2 signaling pathway in arterial smooth muscle tissues of rabbits. (A) A heatmap of the top 200 DEGs in the GSE60887 dataset. (B) A volcano map of the top 200 DEGs in the GSE37924 dataset. (C, D) Annotations of the GO analysis. (E) Partial results of the KEGG pathway analysis. (F–I) The string revealing the gene-enriched items of biological process. (J) Western blotting and quantitative analysis revealed that RhoA, ROCK, and p-ERK1/2 expressions were significantly reduced in the arterial smooth muscle tissues in Fasudil group compared with those in Model group. P<0.05: Fasudil group vs. Model group vs. Sham group.