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Research Paper Volume 14, Issue 18 pp 7378—7389

Fasudil inhibits hepatic artery spasm by repressing the YAP/ERK/ ETA/ETB signaling pathway via inhibiting ROCK activation

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Figure 4. Fasudil restrained the YAP1/ETB/ETA signaling pathway in arterial smooth muscle tissues of rabbits. (A) Immunofluorescence staining indicated decreased immunofluorescence of ETB in Fasudil group compared with that in Model group. P<0.05: Fasudil group vs. Model group. (B) Western blotting showed that Fasudil treatment inhibited the expressions of ETA and ETB proteins. (C–E) Co-expression analysis revealed that YAP1 was significantly correlated with EDN1 (ETA) and EDN2 (ETB) based on the data from the GSE60887 dataset. P<0.05: Fasudil group vs. Sham group. (F–H).