Research Paper Volume 14, Issue 16 pp 6668—6688
MicroRNA-148a induces apoptosis and prevents angiogenesis with bevacizumab in colon cancer through direct inhibition of ROCK1/c-Met via HIF-1α under hypoxia
Figure 7. The anti-cell viability effect of miR-148a on HCT116 and HT-29 colon cancer cells. Four cell lines (HCT116, HCT116-miR148a, HT29, and HT29-miR-148a) were treated with different concentrations of bevacizumab for 24, 48, and 72 h. (A) HCT116 and HCT116-miR148a cells; (B) HT29 and HT29-miR-148a cells. miR-148a significantly inhibited cell viability regardless of the concentration of bevacizumab at 24, 48, and 72 h (all P < 0.001).