Psoralen downregulates osteoarthritis chondrocyte inflammation via an estrogen-like effect and attenuates osteoarthritis

Kui Huang; Bo Wu; Zhuhu Hou; Akhlaq Ahmad; Mushtaq Ahmed; Ayesha Ali Khan; Feng Tian; Fan Cheng; Wei Chu; Ke Deng

doi:doi:10.18632/aging.204245

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Research Paper Volume 14, Issue 16 pp 6716—6726

Psoralen downregulates osteoarthritis chondrocyte inflammation via an estrogen-like effect and attenuates osteoarthritis

Figure 3. Effect of psoralen on inflammatory genes IL-6, TNF-α and IL-1β in OA chondrocytes. E represents estrogen and I represents estrogen receptor antagonist. (A) Expression of IL-6 gene, (B) Expression of TNF-α gene, (C) Expression of IL-1β gene. ** represents P < 0.01, *** represents P < 0.001 compared to control group.