Research Paper Volume 14, Issue 16 pp 6809—6828
LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis
Figure 4. Effect of H19 on ERS-associated apoptosis markers and PI3K/AKT/mTOR pathway in DM. (A) Protein bands exposed the expression of p- PI3K, AKT and mTOR, Nrf2 in each group. (B) Immunofluorescence intensity of GRP78 and p-IRE1a in each group. (C) protein levels of p-PERK, p-IRE1α, ATF6, CHOP, cleaved caspase-3, cleaved caspase-9, cleaved caspase-12, and BAX proteins in all groups. #P < 0.05; ##P < 0.01 vs. DCM group; *P < 0.05; **P < 0.01 vs. sham group, n = 6/group.