Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway

Lianghua Huang; Junwei Kang; Gengfa Chen; Wen Ye; Xiangqiang Meng; Qing Du; Zhen Feng

doi:doi:10.18632/aging.204290

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Research Paper Volume 14, Issue 18 pp 7455—7469

Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway

Figure 6. Low-intensity focused ultrasound (LIFUS) inhibited the activation of NF-κB (nuclear factor κB) and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome after traumatic brain injury (TBI) by orexin-A (OX-A). (A) NF-κB protein levels in the cytoplasm. (B) NF-κB protein levels in the nucleus. (C) Protein levels of NLRP3. (D) NLRP3 corresponding mRNA levels (n=6, SD; *P < 0.05, **P <0.01, ***P < 0.001).