Research Paper Volume 14, Issue 18 pp 7547—7567

Figure 2. Pyroptosis patterns and relevant biological pathway for each pattern. (A) Unsupervised clustering of 30 PRGs in the six CC cohorts. The PPSclusters and cohorts’ names were used as patient annotations. Each column represented patients and each row represented PRGs. (B) Unsupervised clustering analysis of CC patients from 6 GEO cohorts (GSE39582, GSE38832, GSE37892, GSE33113, GSE29621 and GSE17536) resulted in three pyroptosis patterns. Kaplan-Meier curves of relapse-free survival for CC patients in the meta-GEO cohort with different pyroptosis patterns. (C, D) The heatmaps were used to visualize the gene set variation analysis score of representative biological pathways in distinct pyroptosis patterns. The color of orange represented activated pathways and blue represented inhibited pathways. The CC cohorts were used as sample annotations. PPScluster-1 vs. PPScluster-3 (C) and PPScluster-1 vs. PPScluster-2 (D).