Research Paper Volume 14, Issue 18 pp 7547—7567

Figure 5. Analysis of pyroptosis patterns characteristics and tumor somatic mutation. (A) The Kruskal-Wallis test was used to compare the statistical differences of PPSscore among the four molecular subtypes. (B) Survival analyses for low and high PPSscore patient groups in GSE39582 using Kaplan-Meier curves. (C) Survival analyses for subgroup patients classified by PPSscore and treatment with adjuvant chemotherapy (ADJC) using Kaplan-Meier curves. (D) Survival analyses for low and high PPSscore patient groups in the TCGA-COAD cohort using Kaplan-Meier curves. (E, F) Tumor somatic mutation landscape in TCGA-COAD cohort were established according to high PPSscore (E) and low PPSscore (F). Each column represented individual patients. The upper barplot showed TMB. The right number indicated the mutation frequency in each gene. The right barplot showed the proportion of each variant type.