Research Paper Volume 14, Issue 22 pp 8970—8981
Antrodia Camphorata Polysaccharide activates autophagy and regulates NLRP3 degradation to improve liver injury-related inflammatory response
Figure 6. ACP suppressed inflammatory response and activated autophagy. (A–F) As discovered from serum and tissue inflammatory factor detection, the expression of serum and tissue inflammatory factors in D/L group increased, which was significantly higher than that of Control group. While ACP reduced the serum inflammatory factor levels in a dose-dependent manner. *P<0.05 compared with Control, #P<0.05 compared with D/L. (G–I) In protein detection, ACP promoted LC3 expression in tissues while suppressing NLRP3 expression, meanwhile, P62 expression also increased, and the LC3 II/LC3 I ratio increased in tissues. *P<0.05 compared with Control, #P<0.05 compared with D/L.