Research Paper Volume 14, Issue 22 pp 9243—9263
System analysis based on the ER stress-related genes identifies WFS1 as a novel therapy target for colon cancer
Figure 2. Construction of risk model in the GSE40967 cohort. (A) Univariate Cox regression analysis of ERSRGs associated with OS of COAD patients. (B) Lasso regression analysis of the ERSRGs based on univariate Cox regression analysis. (C) Cross-validation for tuning the parameter selection in the LASSO regression. (D) Multivariate cox regression analysis of the ERSRGs based on LASSO regression analysis. (E) Distribution of patients based on the risk score. (F) Kaplan-Meier curve of survival probability of patients in the high-risk group and low-risk group. Statistical tests were performed using the Chi-square test with statistical significance at P < 0.05. (G) Survival time and survival status of patients with different risk scores. (H) The heatmap of the expression of prognostic ERSRGs between high-risk group and low-risk group. (I) ROC curve of risk score and other indicators.