Research Paper Volume 14, Issue 22 pp 9264—9279
CD229 interacts with RASAL3 to activate RAS/ERK pathway in multiple myeloma proliferation
Figure 4. Overexpression of CD229 promotes MM cell proliferation in MM xenograft model. (A) Photographic images of xenograft mice were captured on Day 23. (B) Photographic images of xenografts from SCID/NOD mice. (C) Tumor volume growth curve of NOD/SCID mice. (D) Tumor weight in CD229-OE group was significantly higher than those of WT group. (E) WB assay showed that both CD229 and p-ERK expression were higher in CD229-OE group than WT group derived from xenograft tumors. The data of experiments represent Mean±SD from at least three independent experiments. **p < 0.01.