Research Paper Volume 14, Issue 22 pp 9280—9299

Figure 1. The AOM-DSS model recapitulated “inflammation -CRA-CRC” progression. (A) Schematic representation of the study design. The intestinal conditions and disease progression of mice were evaluated at baseline and 3 weeks, 6 weeks and 12 weeks after intervention. (B) Representative images and H&E staining images (original × magnification 200) of the colon. (C) Body weight, spleen weight, spleen/body (%) change, and number of polyps/tumors in different groups. (D) Alcian blue staining and PAS staining. (E) Alcian blue and PAS staining areas and fluorescence intensity quantified by ImageJ based on different groups. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001.