Research Paper Volume 14, Issue 22 pp 9280—9299
The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers
Figure 2. Identification of circular RNAs expressed at different stages in inflammation-based tumorigenesis. (A) Schematic representation of circRNA identification and sequencing; (B) Cluster based on changes in circRNA; (C) Heatmap of the clustering analysis indicating differences in circRNA expression profiles in the stage of “inflammation-CRA-CRC”. Areas colored red and green indicate the upregulation and downregulation of circRNA, respectively; (D) circRNAs with persistent downregulation; (E) circRNAs with persistent upregulation.