Research Paper Volume 14, Issue 22 pp 9300—9316

Figure 5. CPSF6 knockdown suppressed LUAD cell growth in vivo. Nude mice were transplanted with A549 cells stably expressing CPSF6 shRNA (shCPSF6) or control shRNA (shCtrl) (n=8 per group). (A) One month later, xenograft was formed, and the tumor volume of xenografts was then monitored every 3 days and continued for 33 days. (B) Images of tumor-bearing mice and quantitative IVIS intensity are shown (n=8 per group). (C, D) Xenografts were formed in 8 mice of shCtrl group and 3 mice of shCPSF6 group. These xenografts were collected (C) and weighed (D). *P < 0.05 and ***P<0.001 versus shCtrl.