Exosomes derived from human umbilical cord mesenchymal stem cells promote osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis

Shi-Wei Ren; Guang-Qing Cao; Qing-Run Zhu; Min-Gang He; Fang Wu; Su-Mei Kong; Zhao-Yan Zhang; Qiang Wang; Feng Wang

doi:doi:10.18632/aging.204453

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Research Paper Volume 14, Issue 24 pp 10125—10136

Exosomes derived from human umbilical cord mesenchymal stem cells promote osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis

Figure 3. The expression of PI3KCA (A), PI3KR1 (B) and PTEN (C) was measured using qPCR in the control group, PMO group, PMO+Exos group and exosome group. (D) The expression of p-AKT (Thr308), p-AKT (Ser 473) and total-AKT were detected using western blotting in the control group, PMO group, PMO+Exos group and exosome group. The results of p-AKT (Thr308) (E), p-AKT (Ser 473) (F) were calculated using Image J software.