Research Paper Volume 15, Issue 8 pp 2891—2905

Senescence-related genes define prognosis, immune contexture, and pharmacological response in gastric cancer

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Figure 4. Validation of the key genes expression in GC tissue and single cell localization. (A) Expression of SERPINE1, FEN1, PDGFRB, SNCG, TCF3, and APOC3 between GC tumor and normal tissues in the GSE54129 cohort. (B) Seven cell types identified in the gastric cancer GSE134520 dataset by single cell RNA sequencing (scRNA-seq) profiles and the calculation of uniform manifold approximation and projection (UMAP). (CH) Immunohistochemistry staining in stomach normal tissues (left, upper) and gastric tumor tissues (left, lower), and scRNA-seq expression levels of APOC3 (C), FEN1 (D), PDGFRB (E), SERPINE1 (F), SNCG (G), and TCF3 (H), respectively.