Research Paper Volume 15, Issue 4 pp 1052—1073
TIPE2 acts as a tumor suppressor and correlates with tumor microenvironment immunity in epithelial ovarian cancer
Figure 6. 740Y-P partially antagonized the inhibitory effect of TIPE2 on EOC cells. (A) HeyA8 and SKOV3 cells with stable expression of TIPE2 were incubated with the PI3K agonist 740Y-P. CCK8 assay confirmed that the PI3K agonist 740Y-P could partially reverse the antiproliferation effect of TIPE2 (n=3). (B, C) Transwell migration assay and transwell invasion assay results confirmed that the PI3K agonist 740Y-P can partially reverse the anti-migration and anti-invasion effects of TIPE2 on EOC cells (n=3). (D) Schematic diagram of the anti-tumor activity of TIPE2 in human EOC. Data are presented as mean ± SD. Statistical significance is indicated as: * p < 0.05, ** p < 0.01, *** p < 0.001.