Research Paper Volume 15, Issue 8 pp 2937—2969

FARSB serves as a novel hypomethylated and immune cell infiltration related prognostic biomarker in hepatocellular carcinoma


Figure 8. Associations between FARSB and immune infiltration in HCC. (A) FARSB expression in HCC tissues. (single-cell sequencing) (B) FARSB expression in immune cell in HCC. (single-cell sequencing) (C) FARSB expression in HCC tissues positively correlates with the tumor purity (r=0.113, P=3.48e-02) and infiltration levels of B cells (r=0.326, P=5.95e-10), CD8+ T cells (r=0.176, P=1.09e-03), CD4+ T cells (r=0.266, P=5.76e-07), Macrophages (r=0.388, P=1.01e-13), Neutrophils (r=0.299, P=1.56e-08), and DCs (r=0.287, P=7.18e-08) in HCC tissues. (D) Distribution of FARSB expression across immune subtypes in HCC (TISIDB). The different color plots represent the five immune subtypes (C1: wound healing; C2: IFN-gamma dominant; C3: inflammatory; C4: lymphocyte-depleted and C6: TGF-b dominant). (E) FARSB expression in HCC tissues significantly correlates with T cell checkpoints. (CD80 (r=0.323, P=7.85e-10), CD274 (r=0.147, P=6.16e-03), CD276 (r=0.434, P=2.67e-17), HAVCR2 (r=0.317, P=1.71e-09), LAG3 (r=0.138, P=1.01e-02), PDCD1 (r=0.237, P=8.41e-06)).