Research Paper Volume 15, Issue 10 pp 4084—4095

Figure 1. (A, B) Standardization of GSE83500 dataset, in which blue represents the data before standardization, and red represents the data after standardization. (C) DEGs between two groups of samples in the GSE83500 data set, in which red represents up-regulated genes, blue represents down-regulated genes, and black represents genes with no significant difference in expression (/logFC/>1, P<0.05); (D) Clustering heat map of top 100 differential genes, in which red represents relatively up-regulated genes, blue represents relatively down-regulated genes, and yellow indicates genes with no significant difference in expression. (E, F) Standardization of the GSE83500 data set, where blue represents the data before standardization, and red represents the data after standardization. (G) DEGs between the two groups in the GSE83500 data set, where red represents up-regulated genes, blue represents down-regulated genes, and black represents genes with no significant difference in expression (/logFC/>1, P<0.05); (H) Cluster heat map of top 100 DEGs, where red represents relatively up-regulated genes, blue represents relatively down-regulated genes, and yellow indicates genes with no significant difference in expression. (I) Enrichment of the top 15 up-regulated GO terms. (J) Enrichment function of up-regulated DEGs. (K) Enrichment of the top 15 down-regulated GO terms. (L) Enrichment function of down-regulated DEGs. (M) KEGG pathway analysis of DEGs. (N, O) GSEA of the enrichment pathway. (P) PPI network analysis diagram of enrichment pathways, where red represents up-regulated genes, and blue represents down-regulated genes. (Q) Top 10 target genes in PPI network score. (R) Target genes of miRNA predicted using targetScan. (S) Venn diagram showing common miRNAs. (T) The binding site between mRNAs and miRNAs.