Vascular endothelial growth factor receptor 1 gene (<i>FLT1</i>) longevity variant increases lifespan by reducing mortality risk posed by hypertension

Brian J. Morris; Randi Chen; Timothy A. Donlon; Kalpana J. Kallianpur; Kamal H. Masaki; Bradley J. Willcox

doi:doi:10.18632/aging.204722

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Research Paper Volume 15, Issue 10 pp 3967—3983

Vascular endothelial growth factor receptor 1 gene (FLT1) longevity variant increases lifespan by reducing mortality risk posed by hypertension

Figure 2. Forest plots of mortality risk (hazard ratio and 95% CI) for subjects with and without hypertension for the major allele recessive model and the heterozygous disadvantage model. Shown are results from Cox models adjusted for age, BMI, glucose, smoking (pack-years), alcohol intake (ounces/month), physical activity index, prevalent diseases including CHD, stroke, diabetes, cancer, and depressive symptoms for hypertensive subjects and normotensive subjects according to genotype of FLT1 SNP rs3794396 in (A) the major allele recessive model, GG vs. GC/CC and (B) the heterozygote disadvantage model, GC vs. GG/CC. In men with hypertension who had a longevity-associated genotype, mortality risk was reduced significantly.